Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?
نویسندگان
چکیده
منابع مشابه
Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, re...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2016
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2016.02.006